Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and In...
Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation
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Author / Creator
Hua, Hu , Ge, Xuhua , Wu, Mengqiu , Zhu, Chunhua , Chen, Lihong , Yang, Guangrui , Zhang, Yue , Huang, Songming , Zhang, Aihua and Jia, Zhanjun
Publisher
Basel, Switzerland: S. Karger AG
Journal title
Language
English
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Publication information
Publisher
Basel, Switzerland: S. Karger AG
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Abstract
Background/Aims: In clinic, excessive acetaminophen (APAP) can cause kidney damage with uncertain mechanisms. Recently, accumulating evidence demonstrated a pathogenic role of mitochondrial dysfunction in the kidney injury. Thus, in this study, rotenone, a mitochondrial complex I inhibitor, was applied to the mice with APAP-induced acut...
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Full title
Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a41146c2b9de4c16a6ce29bd5f6e3c46
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a41146c2b9de4c16a6ce29bd5f6e3c46
Other Identifiers
ISSN
1420-4096
E-ISSN
1423-0143
DOI
10.1159/000492589
