The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
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Author / Creator
Zhang, Xiao , Qiao, Yongxia , Wu, Qi , Chen, Yan , Zou, Shaowu , Liu, Xiangfan , Zhu, Guoqing , Zhao, Yinghui , Chen, Yuxin , Yu, Yongchun , Pan, Qiuhui , Wang, Jiayi and Sun, Fenyong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function in liver tumorigenesis is not clear. Here, we demonstrate that O-GlcNAcylation can enhance the expression, stability and function of Yes-associated protein (YAP), the downstream transcriptional regulator of the Hippo pathway and a potent oncogenic f...
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Full title
The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_a41aed7f74b947d7ae8619b5e9637eb2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a41aed7f74b947d7ae8619b5e9637eb2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15280
