Genome-wide analysis yields new loci associating with aortic valve stenosis
Genome-wide analysis yields new loci associating with aortic valve stenosis
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Author / Creator
Helgadottir, Anna , Thorleifsson, Gudmar , Gretarsdottir, Solveig , Stefansson, Olafur A. , Tragante, Vinicius , Thorolfsdottir, Rosa B. , Jonsdottir, Ingileif , Bjornsson, Thorsteinn , Steinthorsdottir, Valgerdur , Verweij, Niek , Nielsen, Jonas B. , Zhou, Wei , Folkersen, Lasse , Martinsson, Andreas , Heydarpour, Mahyar , Prakash, Siddharth , Oskarsson, Gylfi , Gudbjartsson, Tomas , Geirsson, Arnar , Olafsson, Isleifur , Sigurdsson, Emil L. , Almgren, Peter , Melander, Olle , Franco-Cereceda, Anders , Hamsten, Anders , Fritsche, Lars , Lin, Maoxuan , Yang, Bo , Hornsby, Whitney , Guo, Dongchuan , Brummett, Chad M. , Abecasis, Gonçalo , Mathis, Michael , Milewicz, Dianna , Body, Simon C. , Eriksson, Per , Willer, Cristen J. , Hveem, Kristian , Newton-Cheh, Christopher , Smith, J. Gustav , Danielsen, Ragnar , Thorgeirsson, Gudmundur , Thorsteinsdottir, Unnur , Gudbjartsson, Daniel F. , Holm, Hilma , Stefansson, Kari , Faculty of Medicine , Medicinska fakulteten , Sektion II , Cardiovascular Research - Hypertension , Kardiovaskulär forskning - hypertoni , Strategiska forskningsområden (SFO) , Kardiologi , Section II , EpiHealth: Epidemiology for Health , Cardiology , Institutionen för kliniska vetenskaper, Lund , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Lunds universitet , Department of Clinical Sciences, Lund , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Profile areas and other strong research environments and Department of Clinical Sciences, Malmö
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chr...
Alternative Titles
Full title
Genome-wide analysis yields new loci associating with aortic valve stenosis
Authors, Artists and Contributors
Author / Creator
Thorleifsson, Gudmar
Gretarsdottir, Solveig
Stefansson, Olafur A.
Tragante, Vinicius
Thorolfsdottir, Rosa B.
Jonsdottir, Ingileif
Bjornsson, Thorsteinn
Steinthorsdottir, Valgerdur
Verweij, Niek
Nielsen, Jonas B.
Zhou, Wei
Folkersen, Lasse
Martinsson, Andreas
Heydarpour, Mahyar
Prakash, Siddharth
Oskarsson, Gylfi
Gudbjartsson, Tomas
Geirsson, Arnar
Olafsson, Isleifur
Sigurdsson, Emil L.
Almgren, Peter
Melander, Olle
Franco-Cereceda, Anders
Hamsten, Anders
Fritsche, Lars
Lin, Maoxuan
Yang, Bo
Hornsby, Whitney
Guo, Dongchuan
Brummett, Chad M.
Abecasis, Gonçalo
Mathis, Michael
Milewicz, Dianna
Body, Simon C.
Eriksson, Per
Willer, Cristen J.
Hveem, Kristian
Newton-Cheh, Christopher
Smith, J. Gustav
Danielsen, Ragnar
Thorgeirsson, Gudmundur
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Holm, Hilma
Stefansson, Kari
Faculty of Medicine
Medicinska fakulteten
Sektion II
Cardiovascular Research - Hypertension
Kardiovaskulär forskning - hypertoni
Strategiska forskningsområden (SFO)
Kardiologi
Section II
EpiHealth: Epidemiology for Health
Cardiology
Institutionen för kliniska vetenskaper, Lund
Institutionen för kliniska vetenskaper, Malmö
Strategic research areas (SRA)
Lunds universitet
Department of Clinical Sciences, Lund
Profilområden och andra starka forskningsmiljöer
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a44005363a9e4871815257fb6639eafd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a44005363a9e4871815257fb6639eafd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03252-6
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