Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour im...
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL
eff
) responses. Conversely, the induction of protective tumour-specific CTL
eff
and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV) can be engineered to serve as a repli...
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Full title
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_a476030b446346deb07e1f28b441729c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a476030b446346deb07e1f28b441729c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15327
