Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Scl...
Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tuberous sclerosis (TS) is a multi-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and the presence of benign tumors. TS pathology is caused by mutations in tuberous sclerosis complex (
TSC
) genes and is associated with insulin resistance, decreased glycogen synthase kinase 3β (GSK3β) activity, act...
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Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_a4d9a93f97c34c3c8f582aba8a8ebcdd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a4d9a93f97c34c3c8f582aba8a8ebcdd
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-04528-5
