Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF...
Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood. Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of...
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Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_a4e44a22eac149e0a5bfdd849c908dfc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a4e44a22eac149e0a5bfdd849c908dfc
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-25524-3
