Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 va...
Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine
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Author / Creator
Li, Mingyuan , Jia, Lin , Xie, Yanbo , Ma, Wenlin , Yan, Zhihong , Liu, Fufeng , Deng, Jie , Zhu, Ali , Siwei, Xue , Su, Wen , Liu, Xiaofeng , Li, Shiqin , Wang, Haomeng , Yu, Peng and Zhu, Tao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs). Most previous studies have used empirical lyophilization with only a single lyoprotectant, resulting in low lyophil...
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Full title
Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine
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TN_cdi_doaj_primary_oai_doaj_org_article_a4e51f73ed9e406dac79b72acf0367f4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a4e51f73ed9e406dac79b72acf0367f4
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ISSN
2059-0105
E-ISSN
2059-0105
DOI
10.1038/s41541-023-00732-9
