Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies n...
Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated serum leptin. Considering that leptin must cross the blood-brain barrier (BBB) in several regions to enter the brain parenchyma, altered leptin...
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Full title
Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport
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TN_cdi_doaj_primary_oai_doaj_org_article_a535bb02a28d4961be69eb3aff4992b3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a535bb02a28d4961be69eb3aff4992b3
Other Identifiers
ISSN
2045-8118
E-ISSN
2045-8118
DOI
10.1186/s12987-022-00375-3
