Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeab...
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Naturally occurring peptides with high membrane permeability often have ester bonds on their backbones. However, the impact of amide-to-ester substitutions on the membrane permeability of peptides has not been directly evaluated. Here we report the effect of amide-to-ester substitutions on the membrane permeability and conformational ensemble of cy...
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Full title
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides
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TN_cdi_doaj_primary_oai_doaj_org_article_a59489e908164722a8c86ea5023eb75f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a59489e908164722a8c86ea5023eb75f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36978-z
