Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static...
Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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In the development of new drugs, the prediction of metabolite‐to‐parent plasma exposure ratio in humans prior to administration in a clinical study has emerged as an important need. In this work, we derived a mechanistic static model based on first principles to estimate metabolite‐to‐parent plasma exposure ratio, considering the contribution of li...
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Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model
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TN_cdi_doaj_primary_oai_doaj_org_article_a5962f72080f49b789a37b1f1f7d4bc9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a5962f72080f49b789a37b1f1f7d4bc9
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ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.12734
