Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
About this item
Full title
Author / Creator
Mulcahy Levy, Jean M , Zahedi, Shadi , Griesinger, Andrea M , Morin, Andrew , Davies, Kurtis D , Aisner, Dara L , Kleinschmidt-DeMasters, B K , Fitzwalter, Brent E , Goodall, Megan L , Thorburn, Jacqueline , Amani, Vladimir , Donson, Andrew M , Birks, Diane K , Mirsky, David M , Hankinson, Todd C , Handler, Michael H , Green, Adam L , Vibhakar, Rajeev , Foreman, Nicholas K and Thorburn, Andrew
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mechanisms in brain tumors.
mutations occur in many...
Alternative Titles
Full title
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
Authors, Artists and Contributors
Author / Creator
Zahedi, Shadi
Griesinger, Andrea M
Morin, Andrew
Davies, Kurtis D
Aisner, Dara L
Kleinschmidt-DeMasters, B K
Fitzwalter, Brent E
Goodall, Megan L
Thorburn, Jacqueline
Amani, Vladimir
Donson, Andrew M
Birks, Diane K
Mirsky, David M
Hankinson, Todd C
Handler, Michael H
Green, Adam L
Vibhakar, Rajeev
Foreman, Nicholas K
Thorburn, Andrew
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a5f13e09a5a14b12a57161a1ad77d712
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a5f13e09a5a14b12a57161a1ad77d712
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.19671
