Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntingt...
Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease
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Full title
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Publisher
England: The Company of Biologists
Journal title
Language
English
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Publication information
Publisher
England: The Company of Biologists
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Scope and Contents
Contents
While progressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington's disease (HD), the mechanistic basis remains poorly understood. Using chromatin immunoprecipitation and sequencing (ChIP-seq), we show that the huntingtin protein (HTT) reproducibly occupies specific locations in the mouse genome. St...
Alternative Titles
Full title
Altered huntingtin−chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a65eba27d8904afcb1e874cedf231ffd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a65eba27d8904afcb1e874cedf231ffd
Other Identifiers
ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.052282
