Transancestral mapping and genetic load in systemic lupus erythematosus

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a68227bc3ba0457486591e4743061bf9

Transancestral mapping and genetic load in systemic lupus erythematosus

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Langefeld, Carl D. , Ainsworth, Hannah C. , Graham, Deborah S. Cunninghame , Kelly, Jennifer A. , Comeau, Mary E. , Marion, Miranda C. , Howard, Timothy D. , Ramos, Paula S. , Croker, Jennifer A. , Morris, David L. , Sandling, Johanna K. , Almlöf, Jonas Carlsson , Acevedo-Vásquez, Eduardo M. , Alarcón, Graciela S. , Babini, Alejandra M. , Baca, Vicente , Bengtsson, Anders A. , Berbotto, Guillermo A. , Bijl, Marc , Brown, Elizabeth E. , Cardiel, Mario H. , Catoggio, Luis , Cervera, Ricard , Cucho-Venegas, Jorge M. , Dahlqvist, Solbritt Rantapää , D’Alfonso, Sandra , Da Silva, Berta Martins , de la Rúa Figueroa, Iñigo , Doria, Andrea , Edberg, Jeffrey C. , Endreffy, Emőke , Esquivel-Valerio, Jorge A. , Fortin, Paul R. , Freedman, Barry I. , Frostegård, Johan , García, Mercedes A. , de la Torre, Ignacio García , Gilkeson, Gary S. , Gunnarsson, Iva , Guthridge, Joel M. , Huggins, Jennifer L. , James, Judith A. , Kallenberg, Cees G. M. , Kamen, Diane L. , Karp, David R. , Kaufman, Kenneth M. , Kovács, László , Lauwerys, Bernard R. , Li, Quan-Zhen , Maradiaga-Ceceña, Marco A. , Martín, Javier , McCune, Joseph M. , McWilliams, David R. , Merrill, Joan T. , Miranda, Pedro , Moctezuma, José F. , Nath, Swapan K. , Niewold, Timothy B. , Ortego-Centeno, Norberto , Petri, Michelle , Pineau, Christian A. , Pons-Estel, Bernardo A. , Pope, Janet , Raj, Prithvi , Reveille, John D. , Russell, Laurie P. , Sabio, José M. , Aguilar-Salinas, Carlos A. , Scorza, Raffaella , Seldin, Michael F. , Sjöwall, Christopher , Svenungsson, Elisabet , Thompson, Susan D. , Toloza, Sergio M. A. , Truedsson, Lennart , Tusié-Luna, Teresa , Vasconcelos, Carlos , Vilá, Luis M. , Wallace, Daniel J. , Weisman, Michael H. , Wither, Joan E. , Bhangale, Tushar , Oksenberg, Jorge R. , Rioux, John D. , Gregersen, Peter K. , Syvänen, Ann-Christine , Rönnblom, Lars , Criswell, Lindsey A. , Sivils, Kathy L. , Tsao, Betty P. , Schanberg, Laura E. , Behrens, Timothy W. , Silverman, Earl D. , Alarcón-Riquelme, Marta E. , Kimberly, Robert P. , Harley, John B. , Wakeland, Edward K. , Graham, Robert R. , Gaffney, Patrick M. , Vyse, Timothy J. , et al , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Sektion III , Department of Laboratory Medicine , EpiHealth: Epidemiology for Health , Institutionen för kliniska vetenskaper, Lund , Strategic research areas (SRA) , Division of Microbiology, Immunology and Glycobiology - MIG , Lunds universitet , Department of Clinical Sciences, Lund , Rheumatology , Profilområden och andra starka forskningsmiljöer , Lund University , Section III , Institutionen för laboratoriemedicin , Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG , Lund SLE Research Group , Reumatologi och molekylär skelettbiologi and Profile areas and other strong research environments

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London: Nature Publishing Group UK

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Nature communications, 2017-07, Vol.8 (1), p.16021-18, Article 16021

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English

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London: Nature Publishing Group UK

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Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in...