Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitabi...
Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutations of the Na
+
-activated K
+
channel Slack (
KCNT1
) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knockout mice (Slack
−/−
) in vivo. Fittingly, we find exacerbation of cell death foll...
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Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
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TN_cdi_doaj_primary_oai_doaj_org_article_a6c08612daa049a9a70afd552cb8e96a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a6c08612daa049a9a70afd552cb8e96a
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-05387-9
