Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
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England: BMJ Publishing Group Ltd
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English
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England: BMJ Publishing Group Ltd
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BackgroundTransgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, compromising the amount of therapeutic protein expressed. Studying the oncolytic herpes simplex virus-1...
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Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
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TN_cdi_doaj_primary_oai_doaj_org_article_a6f957f1406d4b8b8ac61e2d28561a27
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a6f957f1406d4b8b8ac61e2d28561a27
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-006408
