High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The homo-dimeric bacterial membrane protein EmrE effluxes polyaromatic cationic substrates in a proton-coupled manner to cause multidrug resistance. We recently determined the structure of substrate-bound EmrE in phospholipid bilayers by measuring hundreds of protein-ligand H
N
–F distances for a fluorinated substrate, 4-fluoro-tetraphenylpho...
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High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
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TN_cdi_doaj_primary_oai_doaj_org_article_a6ff24e0a3844b76b2840e90afda18df
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a6ff24e0a3844b76b2840e90afda18df
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28556-6
