A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficien...
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
About this item
Full title
Author / Creator
Lightwood, Daniel J. , Munro, Rebecca J. , Porter, John , McMillan, David , Carrington, Bruce , Turner, Alison , Scott-Tucker, Anthony , Hickford, Elizabeth S. , Schmidt, Antje , Fox, David , Maloney, Alison , Ceska, Tom , Bourne, Tim , O’Connell, James , Lawson, Alastair D. G. and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
We have recently described the development of a series of small-molecule inhibitors of human tumour necrosis factor (TNF) that stabilise an open, asymmetric, signalling-deficient form of the soluble TNF trimer. Here, we describe the generation, characterisation, and utility of a monoclonal antibody that selectively binds with high affinity to the a...
Alternative Titles
Full title
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Authors, Artists and Contributors
Author / Creator
Munro, Rebecca J.
Porter, John
McMillan, David
Carrington, Bruce
Turner, Alison
Scott-Tucker, Anthony
Hickford, Elizabeth S.
Schmidt, Antje
Fox, David
Maloney, Alison
Ceska, Tom
Bourne, Tim
O’Connell, James
Lawson, Alastair D. G.
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a700e6f6d0e341fa8bbbdf0203d53866
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a700e6f6d0e341fa8bbbdf0203d53866
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20825-6
