Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine product...
Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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The anti-inflammatory effect of abatacept is most pronounced in patients with high-titer autoantibodies (including anticitrullinated protein antibodies [ACPA] and rheumatoid factor [RF]). Considering that autoantibodies trigger inflammatory cytokine production by monocytes and that abatacept binds to monocytes, influencing their functional state, w...
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Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner
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TN_cdi_doaj_primary_oai_doaj_org_article_a71ffcbebe68475c96b16a3bf722cf5b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a71ffcbebe68475c96b16a3bf722cf5b
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ISSN
1478-6362,1478-6354
E-ISSN
1478-6362
DOI
10.1186/s13075-018-1527-x
