Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
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Author / Creator
Jiang, Yuhan , Li, Yixiao , Liu, Cheng , Zhang, Lei , Lv, Danyu , Weng, Yejing , Cheng, Zhongyi , Chen, Xiangmei , Zhan, Jun and Zhang, Hongquan
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Isoniazid (INH) is a first-line anti-tuberculosis drug used for nearly 70 years. However, the mechanism underlying the side effects of INH has remained elusive. Here, we report that INH and its metabolites induce a post-translational modification (PTM) of histones, lysine isonicotinylation (K
inic
), also called 4-picolinylation, in cells and...
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Full title
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
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TN_cdi_doaj_primary_oai_doaj_org_article_a75ea7e77a4d4edc993060b25acbbf6e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a75ea7e77a4d4edc993060b25acbbf6e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25867-y
