Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tum...
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
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Author / Creator
Liu, Yuan , Guo, Ji-Zheng , Liu, Ying , Wang, Kui , Ding, Wencheng , Wang, Hui , Liu, Xiang , Zhou, Shengtao , Lu, Xiao-Chen , Yang, Hong-Bin , Xu, Chenyue , Gao, Wei , Zhou, Li , Wang, Yi-Ping , Hu, Weiguo , Wei, Yuquan , Huang, Canhua and Lei, Qun-Ying
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) preferably locates in the nucleus in HPV16-positive cervical tumors due to E7-induced intracellular r...
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Full title
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
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TN_cdi_doaj_primary_oai_doaj_org_article_a77265bfdf7b44d1aae182171c371652
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a77265bfdf7b44d1aae182171c371652
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06841-7
