Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons...
Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pitt-Hopkins syndrome (PTHS) is a rare autism spectrum-like disorder characterized by intellectual disability, developmental delays, and breathing problems involving episodes of hyperventilation followed by apnea. PTHS is caused by functional haploinsufficiency of the gene encoding transcription factor 4 (
Tcf4
). Despite the severity of this...
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Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression
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TN_cdi_doaj_primary_oai_doaj_org_article_a78313bc494446f49687e53a00a1780f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a78313bc494446f49687e53a00a1780f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26263-2
