Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target module (TM) which is characterized by a small-size and short half-life. The rapid clearance of these TMs from the blood allows a quick steering...
Alternative Titles
Full title
Extended half-life target module for sustainable UniCAR T-cell treatment of STn-expressing cancers
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a79309c630b94b63ab1652bbb82d83be
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a79309c630b94b63ab1652bbb82d83be
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-020-01572-4
