A neuronal network of mitochondrial dynamics regulates metastasis
A neuronal network of mitochondrial dynamics regulates metastasis
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. W...
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A neuronal network of mitochondrial dynamics regulates metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_a83307e942fa4962afc59efab303f2dc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a83307e942fa4962afc59efab303f2dc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13730
