Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenome...
Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colorectal cancer (CRC). Analysis of a genetica...
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Full title
Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes
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TN_cdi_doaj_primary_oai_doaj_org_article_a8619f27054e40b480d81c4ee548d4dd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8619f27054e40b480d81c4ee548d4dd
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.40760
