Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 i...
Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers
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Author / Creator
Li, Xiang , He, Na , Lv, Yan , Wang, Haiyue , Zhang, Ming , Zhai, Heiyan , Yang, Zhen , Yang, Yi , Guo, Dagang , Cao, Zhixiang and Chen, Yiyou
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ubiquitin from target proteins, rescuing them from degradation. Here, we characterized the small molecul...
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Full title
Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_a864ce0fe85d43fc8778ee6f1cdac7ca
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a864ce0fe85d43fc8778ee6f1cdac7ca
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-88761-3
