Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neut...
Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma
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Author / Creator
Deng, Haijing , Kan, Anna , Lyu, Ning , He, Meng , Huang, Xin , Qiao, Shuang , Li, Shaolong , Lu, Wenhua , Xie, Qiankun , Chen, Huiming , Lai, Jinfa , Chen, Qifeng , Jiang, Xiongying , Liu, Shousheng , Zhang, Zhenfeng and Zhao, Ming
Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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BackgroundNeutrophils play a controversial role in tumor development. The function of programmed cell death-1 ligand (PD-L1+) neutrophils, however, may inhibit the cytotoxicity of anti-tumor immunity. In this study, we elucidate the stimulators of PD-L1+ neutrophils in tumor microenvironment (TME) and explore the optimal combination to enhance the...
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Full title
Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_a8727dadc0ff402fa3eb3d40ae114036
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8727dadc0ff402fa3eb3d40ae114036
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-002305
