A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
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Author / Creator
Dabral, Swati , Muecke, Christian , Valasarajan, Chanil , Schmoranzer, Mario , Wietelmann, Astrid , Semenza, Gregg L. , Meister, Michael , Muley, Thomas , Seeger-Nukpezah, Tamina , Samakovlis, Christos , Weissmann, Norbert , Grimminger, Friedrich , Seeger, Werner , Savai, Rajkumar and Pullamsetti, Soni S.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized by a glycolytic switch similar to the Warburg effect in cancer. Ras association domain family 1A (RASSF1A) is a scaffold protein that acts as a tumour suppressor. Here we s...
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Full title
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
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TN_cdi_doaj_primary_oai_doaj_org_article_a8901cfbf7474186b10f84b921b3e98d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8901cfbf7474186b10f84b921b3e98d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10044-z
