Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is 8-oxoguanine (8-oxoG), and its accumulation in mitochondrial DNA (mtDNA) induces cell dysfunction and death, leading to the hypothesis that...
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Full title
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis
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TN_cdi_doaj_primary_oai_doaj_org_article_a8fd98b45fab417883bf96e9c8ffd705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a8fd98b45fab417883bf96e9c8ffd705
Other Identifiers
ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-022-02616-6
