Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduce...
Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosine
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England: Nature Publishing Group
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English
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England: Nature Publishing Group
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Cryptococcal meningitis is a high-mortality infection. Adding 5-fluorocytosine (5-FC) to its treatment improves outcomes, but resistance to 5-FC presents a significant challenge. We conducted whole-genome sequencing on seven C. neoformans isolates with varying 5-FC susceptibility, along with proteomic and in silico analyses. Our findings indicate t...
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Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosine
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TN_cdi_doaj_primary_oai_doaj_org_article_a90c5da1a1884c8d96a3de3bdc41a70b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a90c5da1a1884c8d96a3de3bdc41a70b
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ISSN
2731-8745
E-ISSN
2731-8745
DOI
10.1038/s44259-024-00041-8
