Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age
Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes. Skewed XCI toward one parental X has been observed in several complex human traits, but the extent to which genetics and environment influence skewed XCI is largely unexplored. To address this, we quantify XCI-skew in multiple tissues and...
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Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age
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TN_cdi_doaj_primary_oai_doaj_org_article_a930e629700d41afa50c28ffc5023117
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a930e629700d41afa50c28ffc5023117
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13340-w
