Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
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Author / Creator
Sigmund, Anna M. , Winkler, Markus , Engelmayer, Sophia , Kugelmann, Daniela , Egu, Desalegn T. , Steinert, Letyfee S. , Fuchs, Michael , Hiermaier, Matthias , Radeva, Mariya Y. , Bayerbach, Franziska C. , Butz, Elisabeth , Kotschi, Stefan , Hudemann, Christoph , Hertl, Michael , Yeruva, Sunil , Schmidt, Enno , Yazdi, Amir S. , Ghoreschi, Kamran , Vielmuth, Franziska and Waschke, Jens
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on suppression of autoantibody formation and thus treatments directly stabilizing keratinocyte adhesion would fulfill an unmet medical need. We here demonstrate that apremilast, a phosphodiesterase 4 i...
Alternative Titles
Full title
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
Authors, Artists and Contributors
Author / Creator
Winkler, Markus
Engelmayer, Sophia
Kugelmann, Daniela
Egu, Desalegn T.
Steinert, Letyfee S.
Fuchs, Michael
Hiermaier, Matthias
Radeva, Mariya Y.
Bayerbach, Franziska C.
Butz, Elisabeth
Kotschi, Stefan
Hudemann, Christoph
Hertl, Michael
Yeruva, Sunil
Schmidt, Enno
Yazdi, Amir S.
Ghoreschi, Kamran
Vielmuth, Franziska
Waschke, Jens
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a933bd3a4505443a83704c045d6c6602
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a933bd3a4505443a83704c045d6c6602
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-35741-0
