MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression
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Author / Creator
Liu, Jie , Wei, Xujin , Xie, Yixuan , Yan, Yuxiang , Xue, Sihui , Wang, Xiangyu , Chen, Han , Pan, Qilong , Yan, Sisi , Zheng, Xiaoling and Huang, Qingling
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
MDM4 is one of the major regulators of p53. The biological effect of MDM4 on tumor is controversial, its role and molecular mechanism in colon cancer progression and prognosis are still unclear. In this study, we identify that MDM4 is significantly overexpressed in human colon cancer and high MDM4 expression was associated with poor prognosis of co...
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Full title
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression
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TN_cdi_doaj_primary_oai_doaj_org_article_a96cdad7a2eb49bea6735f001b16f54b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a96cdad7a2eb49bea6735f001b16f54b
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07227-y
