Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensati...
Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we characterize a family of binuclear ruthenium compounds th...
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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
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TN_cdi_doaj_primary_oai_doaj_org_article_a9b55ad0f6804689b89dc6a03944e55c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a9b55ad0f6804689b89dc6a03944e55c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01680-4
