A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 ac...
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys mutation of the
ALDH2
gene is prevalent in 560 million East Asians, resulting in reduced ALDH2 enzymatic acti...
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Full title
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
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TN_cdi_doaj_primary_oai_doaj_org_article_aa0c7baef0c6434fba0dad49f77f4be3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa0c7baef0c6434fba0dad49f77f4be3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41570-6
