Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The polyketide natural product reveromycin A (RM-A) exhibits antifungal, anticancer, anti-bone metastasis, anti-periodontitis and anti-osteoporosis activities by selectively inhibiting eukaryotic cytoplasmic isoleucyl-tRNA synthetase (IleRS). Herein, a co-crystal structure suggests that the RM-A molecule occupies the substrate tRNA
Ile
bindin...
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Full title
Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
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TN_cdi_doaj_primary_oai_doaj_org_article_aa106fd7577240a4b8e1ff9e7d96b4fa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa106fd7577240a4b8e1ff9e7d96b4fa
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21902-0
