p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self...
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β-p38
MAPK
balances HSPC self-renewal and differentiation. Upon transplantation, HSPCs express high amounts of bioactive TGF-β1 protein, which is associated with high levels...
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Full title
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
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TN_cdi_doaj_primary_oai_doaj_org_article_aa4e1e51138e4312ba30120be3566b6b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa4e1e51138e4312ba30120be3566b6b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14382
