Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney in...
Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis
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Author / Creator
Yuan, Yujia , Yuan, Longhui , Yang, Jingchao , Liu, Fei , Liu, Shuyun , Li, Lan , Liao, Guangneng , Tang, Xi , Cheng, Jingqiu , Liu, Jingping , Chen, Younan and Lu, Yanrong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Macrophages (Mφ) autophagy is a pivotal contributor to inflammation-related diseases. However, the mechanistic details of its direct role in acute kidney injury (AKI) were unclear. Here, we show that Mφ promote AKI progression via crosstalk with tubular epithelial cells (TECs), and autophagy of Mφ was activated and then inhibited in cisplatin-induc...
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Full title
Autophagy-deficient macrophages exacerbate cisplatin-induced mitochondrial dysfunction and kidney injury via miR-195a-5p-SIRT3 axis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_aa58c616ab08413db1b6d2eddbc13b21
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa58c616ab08413db1b6d2eddbc13b21
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47842-z
