Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homo...
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high rate of resistance in this subset of patients to PARP inhibitors (PARPi). To overcome resistance to PARPi and to broaden their...
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Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_aa58f0bfd0a740678bf052d1f92375c9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa58f0bfd0a740678bf052d1f92375c9
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03475-4
