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NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrop...

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrop...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa724b3e4c7b4ada9b67a708841b1195

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

About this item

Full title

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-08, Vol.9 (1), p.3431-14, Article 3431

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously, we showed that NF-κB exacerbates DMD skeletal muscle pathology by promoting inflammation and impairi...

Alternative Titles

Full title

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_aa724b3e4c7b4ada9b67a708841b1195

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_aa724b3e4c7b4ada9b67a708841b1195

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-05910-1

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