The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
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Du, Tongde , Li, Hongchang , Fan, Yongsheng , Yuan, Lin , Guo, Xiaodan , Zhu, Qiong , Yao, Yuying , Li, Xin , Liu, Chunlei , Yu, Xinhe , Liu, Zhaofei , Cui, Chun-Ping , Han, Chuanchun and Zhang, Lingqiang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras
G12D
-driven lung adenocarcinoma (ADC) initiation an...
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Full title
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_ab1f8b5e1844405cb2061fdd5a0b4699
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab1f8b5e1844405cb2061fdd5a0b4699
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10824-7
