Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple m...
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma
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Author / Creator
Bajpai, Richa , Sharma, Aditi , Achreja, Abhinav , Edgar, Claudia L. , Wei, Changyong , Siddiqa, Arusha A. , Gupta, Vikas A. , Matulis, Shannon M. , McBrayer, Samuel K. , Mittal, Anjali , Rupji, Manali , Barwick, Benjamin G. , Lonial, Sagar , Nooka, Ajay K. , Boise, Lawrence H. , Nagrath, Deepak and Shanmugam, Mala
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the
11;14
translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine that venetoclax-sensitive myeloma has reduced mitochondrial respiration. Consistent...
Alternative Titles
Full title
Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ab542c51a366402d8b83cd98c687f243
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab542c51a366402d8b83cd98c687f243
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15051-z
