Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino aci...
Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Hundreds of non-proteinogenic (np) amino acids (AA) are found in plants and can in principle enter human protein synthesis through foods. While aminoacyl-tRNA synthetase (AARS) editing potentially provides a mechanism to reject np AAs, some have pathological associations. Co-crystal structures show that vegetable-sourced azetidine-2-carboxylic acid...
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Full title
Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
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TN_cdi_doaj_primary_oai_doaj_org_article_ab6942f80cab4c61b84fff08d09c316d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab6942f80cab4c61b84fff08d09c316d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02201-z
