CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital...
CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease
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Publisher
The Company of Biologists Ltd
Journal title
Language
English
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Publisher
The Company of Biologists Ltd
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Contents
High-throughput DNA sequencing studies increasingly associate DNA variants with congenital heart disease (CHD). However, functional modeling is a crucial prerequisite for translating genomic data into clinical care. We used CRISPR-Cas9-mediated targeting of 12 candidate genes in the vertebrate model medaka (Oryzias latipes), five of which displayed...
Alternative Titles
Full title
CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease
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TN_cdi_doaj_primary_oai_doaj_org_article_ab697a95f9f84a279d1e225aea755ec8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab697a95f9f84a279d1e225aea755ec8
Other Identifiers
ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.049811
