Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest...
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
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Author / Creator
Wang, Heming , Lane, Jacqueline M. , Jones, Samuel E. , Dashti, Hassan S. , Ollila, Hanna M. , Wood, Andrew R. , van Hees, Vincent T. , Brumpton, Ben , Winsvold, Bendik S. , Kantojärvi, Katri , Palviainen, Teemu , Cade, Brian E. , Sofer, Tamar , Song, Yanwei , Patel, Krunal , Anderson, Simon G. , Bechtold, David A. , Bowden, Jack , Emsley, Richard , Kyle, Simon D. , Little, Max A. , Loudon, Andrew S. , Scheer, Frank A. J. L. , Purcell, Shaun M. , Richmond, Rebecca C. , Spiegelhalder, Kai , Tyrrell, Jessica , Zhu, Xiaofeng , Hublin, Christer , Kaprio, Jaakko A. , Kristiansson, Kati , Sulkava, Sonja , Paunio, Tiina , Hveem, Kristian , Nielsen, Jonas B. , Willer, Cristen J. , Zwart, John-Anker , Strand, Linn B. , Frayling, Timothy M. , Ray, David , Lawlor, Deborah A. , Rutter, Martin K. , Weedon, Michael N. , Redline, Susan and Saxena, Richa
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggr...
Alternative Titles
Full title
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Authors, Artists and Contributors
Author / Creator
Lane, Jacqueline M.
Jones, Samuel E.
Dashti, Hassan S.
Ollila, Hanna M.
Wood, Andrew R.
van Hees, Vincent T.
Brumpton, Ben
Winsvold, Bendik S.
Kantojärvi, Katri
Palviainen, Teemu
Cade, Brian E.
Sofer, Tamar
Song, Yanwei
Patel, Krunal
Anderson, Simon G.
Bechtold, David A.
Bowden, Jack
Emsley, Richard
Kyle, Simon D.
Little, Max A.
Loudon, Andrew S.
Scheer, Frank A. J. L.
Purcell, Shaun M.
Richmond, Rebecca C.
Spiegelhalder, Kai
Tyrrell, Jessica
Zhu, Xiaofeng
Hublin, Christer
Kaprio, Jaakko A.
Kristiansson, Kati
Sulkava, Sonja
Paunio, Tiina
Hveem, Kristian
Nielsen, Jonas B.
Willer, Cristen J.
Zwart, John-Anker
Strand, Linn B.
Frayling, Timothy M.
Ray, David
Lawlor, Deborah A.
Rutter, Martin K.
Weedon, Michael N.
Redline, Susan
Saxena, Richa
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ab82094d6f1747f6b19a7f7da87c85b4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab82094d6f1747f6b19a7f7da87c85b4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11456-7
