Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clini...
Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and treatment resistance. To date, successful targeted treatment options f...
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Full title
Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course
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TN_cdi_doaj_primary_oai_doaj_org_article_ab8d7da124964dd89f2c5fdc280d36be
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ab8d7da124964dd89f2c5fdc280d36be
Other Identifiers
ISSN
1746-1596
E-ISSN
1746-1596
DOI
10.1186/s13000-024-01511-3
