Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Identifying transcription factors (TFs) whose DNA bindings are altered by genetic variants that regulate susceptibility genes is imperative to understand transcriptional dysregulation in disease etiology. Here, we develop a statistical framework to analyze extensive ChIP-seq and GWAS data and identify 22 breast cancer risk-associated TFs. We find t...
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Full title
Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
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TN_cdi_doaj_primary_oai_doaj_org_article_abb3d8fa43c245a99dfc68464a409310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_abb3d8fa43c245a99dfc68464a409310
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25670-9
