TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitinatio...
TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3
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Author / Creator
Wang, Peng , Zhao, Wei , Zhao, Kai , Zhang, Lei and Gao, Chengjiang
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection. IRF3 activation requires phosphorylation, dimerization and nuclear translocation. However, the mechanis...
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Full title
TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3
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Author / Creator
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TN_cdi_doaj_primary_oai_doaj_org_article_abf0e1dee2874f86846de2fea1ea7e69
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_abf0e1dee2874f86846de2fea1ea7e69
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1004726
