Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells
Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, leading to uncontrolled cell proliferation. Palbociclib, a smal...
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Full title
Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells
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TN_cdi_doaj_primary_oai_doaj_org_article_ac084253a0834a438af54a7d59f2f68e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac084253a0834a438af54a7d59f2f68e
Other Identifiers
ISSN
1475-2867
E-ISSN
1475-2867
DOI
10.1186/s12935-020-01357-x
