cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning
cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module has a critical role in a presynaptic form of long-term potentiation in the cerebellum and motor behavior in mice. Presynaptic cAMP−EPAC−PKCε signaling cascade induces...
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cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning
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TN_cdi_doaj_primary_oai_doaj_org_article_ac0da0bbab3d459799ea9333440949dd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac0da0bbab3d459799ea9333440949dd
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.80875
