Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phen...
Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice
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Author / Creator
Gould, Nathaniel L. , Scherer, Gila R. , Carvalho, Silvia , Shurrush, Khriesto , Kayyal, Haneen , Edry, Efrat , Elkobi, Alina , David, Orit , Foqara, Maria , Thakar, Darshit , Pavesi, Tommaso , Sharma, Vijendra , Walker, Matthew , Maitland, Matthew , Dym, Orly , Albeck, Shira , Peleg, Yoav , Germain, Nicolas , Babaev, Ilana , Sharir, Haleli , Lalzar, Maya , Shklyar, Boris , Hazut, Neta , Khamaisy, Mohammad , Lévesque, Maxime , Lajoie, Gilles , Avoli, Massimo , Amitai, Gabriel , Lefker, Bruce , Subramanyam, Chakrapani , Shilton, Brian , Barr, Haim and Rosenblum, Kobi
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, in which QR2 acts as a removable memory constraint and metabolic buffer within neurons. QR2 becomes ove...
Alternative Titles
Full title
Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer’s disease phenotype in mice
Authors, Artists and Contributors
Author / Creator
Scherer, Gila R.
Carvalho, Silvia
Shurrush, Khriesto
Kayyal, Haneen
Edry, Efrat
Elkobi, Alina
David, Orit
Foqara, Maria
Thakar, Darshit
Pavesi, Tommaso
Sharma, Vijendra
Walker, Matthew
Maitland, Matthew
Dym, Orly
Albeck, Shira
Peleg, Yoav
Germain, Nicolas
Babaev, Ilana
Sharir, Haleli
Lalzar, Maya
Shklyar, Boris
Hazut, Neta
Khamaisy, Mohammad
Lévesque, Maxime
Lajoie, Gilles
Avoli, Massimo
Amitai, Gabriel
Lefker, Bruce
Subramanyam, Chakrapani
Shilton, Brian
Barr, Haim
Rosenblum, Kobi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ac5cf5dd51f14d3ba8d30c4735cde0de
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ac5cf5dd51f14d3ba8d30c4735cde0de
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI162120
